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    Essentials of Diagnostic Breast Pathology

    A Practical Approach

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    Essentials of Diagnostic Breast Pathology
    A Practical Approach

    Autoren:

    Verlag:
    Springer-Verlag   Weitere Titel dieses Verlages anzeigen

    Erschienen: Februar 2007
    Seiten: 496
    Sprache: Englisch
    Illustration: 1128 farb. Abb.
    Maße: 323x256x37
    Einband: Leinen (Buchleinen)
    ISBN: 354045117x
    EAN: 9783540451174

    Inhaltsverzeichnis

    Contents
    1The Normal Breast
     1.1Anatomy2
     1.2Pregnancy and Lactation2
     1.3Menopause3
     1.4Immunoprofile3
     1.5Further Reading3
    2Specimen Processing
     2.1Frozen Section8
     2.2Core Needle Biopsy9
     2.3Excisional Biopsy10
     2.4Mastectomy11
     2.5Axillary Lymph Nodes11
     2.6Sentinel Lymph Nodes12
     2.7Further Reading12
    3Fibrocystic Change and Duct Ectasia
     3.1Fibrocystic Change16
     3.2Duct Ectasia (Periductal Mastitis)17
    4Adenosis
     4.1Definition,Types, and Macroscopy of Adenosis28
     4.2Blunt Duct Adenosis28
     4.3Sclerosing Adenosis29
     4.4Apocrine Adenosis (Adenosis with Apocrine Metaplasia)30
     4.5Tubular Adenosis31
     4.6Adenomyoepithelial Adenosis31
     4.7Microglandular Adenosis32
     4.8Radial Scar/Complex Sclerosing Lesion32
     4.9Collagenous Spherulosis34
    5Intraductal Proliferative Lesions
     5.1Usual Ductal Hyperplasia68
     5.2Ductal Intraepithelial Neoplasia (DIN)70
     5.3Ductal Intraepithelial Neoplasia (DIN), Flat Type72
     5.4Low-Grade Ductal Intraepithelial Neoplasia (WHO: DIN1b; Atypical Ductal Hyperplasia)74
     5.5Ductal Intraepithelial Neoplasia (WHO: DIN1c-DIN3,DCIS)76
    6Intraductal Papillary Neoplasms
     6.1Central Papilloma124
     6.2Peripheral Papilloma124
     6.3Sclerosing Papilloma125
     6.4Intraductal Papillary Carcinoma (Papillary Ductal Intraepithelial Neoplasia)125
     6.5Role of Immunohistochemistry in Diagnosing Intraductal Papillary Neoplasms126
     6.6Additional Comments126
     6.7Further Reading127
    7Lobular Intraepithelial Neoplasia (LIN)
     7.1Synonyms156
     7.2Background156
     7.3Microscopic Features156
     7.4Additional Comments156
     7.5Further Reading157
    8Infiltrating Ductal Carcinoma (NOS Type)
     8.1Definition180
     8.2Macroscopy180
     8.3Microscopic Features180
     8.4Grading180
     8.5Additional Comments181
     8.6Further Reading181
    9Invasive Lobular Carcinoma (ILC)
     9.1Macroscopy192
     9.2Microscopic Features192
     9.3Additional Comments192
     9.4Immunohistochemistry of LIN and ILC192
     9.5Grading192
     9.6Further Reading193
    10Special Types of Breast Carcinomas
     10.1Tubular Carcinoma223
     10.2Mucin-Producing Carcinomas of the Breast224
     10.3Carcinoma with Neuroendocrine Differentiation226
     10.4Invasive Papillary Carcinoma227
     10.5Invasive Micropapillary Carcinoma227
     10.6Apocrine Carcinoma228
     10.7Secretory Carcinoma229
     10.8Adenoid Cystic Carcinoma230
     10.9Acinic Cell Carcinoma231
     10.10Sebaceous Carcinoma232
     10.11Infiltrating Cribriform Carcinoma232
     10.12Medullary Carcinoma233
     10.13Metaplastic Carcinomas234
     10.14Clear Cell (Glycogen-Rich) Carcinoma237
     10.15Lipid-Rich Carcinoma (Lipid-Secreting Carcinoma)238
     10.16Metastatic Carcinoma238
     10.17Inflammatory Carcinoma239
    11Biphasic Tumors
     11.1Fibroadenoma320
     11.2Phylloides Tumor321
    12Diseases of the Nipple
     12.1Paget's Disease352
     12.2Nipple Duct Adenoma353
     12.3(Infiltrating) Syringomatous Adenoma354
    13Male Breast Lesions
     13.1Gynecomastia366
     13.2Papilloma367
     13.3Primary Male Breast Carcinoma367
     13.4Further Reading367
    14Mesenchymal Lesions/Tumors
     14.1Stromal Elastosis377
     14.2Fat Necrosis377
     14.3Metaplasias378
     14.4Pseudoangiomatous Stromal Hyperplasia378
     14.5Fibromatosis379
     14.6Myofibroblastoma380
     14.7Lipoma381
     14.8Angiolipoma381
     14.9Granular Cell Tumor382
     14.10Hamartoma383
     14.11Perilobular Hemangioma383
     14.12Hemangioma384
     14.13Angiomatosis384
     14.14Angiosarcoma385
     14.15Leiomyosarcoma386
     14.16Liposarcoma387
     14.17Rhabdomyosarcoma387
     14.18Malignant Fibrous Histiocytoma388
     14.19Osteosarcoma389
     14.20Spindle Cell Sarcoma, Not Otherwise Specified (NOS-Type Mammary Sarcoma)389
    15Myoepithelial Lesions/Neoplasms
     15.1Background410
     15.2Immunoprofile410
     15.3Myoepithelial Cell Hypertrophy410
     15.4Myoepitheliosis (Myoepithelial Hyperplasia)411
     15.5Adenomyoepithelioma411
     15.6Sarcomatoid Carcinoma with Myoepithelial Differentiation (Myoepithelial Carcinoma, Malignant Myoepithelioma)412
    16Miscellaneous Lesions
     16.1Acute Mastitis (Puerperal Mastitis)420
     16.2Subareolar Abscess420
     16.3Plasma Cell Mastitis420
     16.4Idiopathic Granulomatous Mastitis421
     16.5Lymphocytic Mastitis (Diabetic Mastopathy)421
     16.6Eosinophilic Mastitis422
     16.7Silicone Mastitis and Diseases Associated with Cosmetic Augmentation422
     16.8Further Reading422
     16.9Pathologic Effects of Adjuvant Radiotherapy423
     16.10Pathologic Effects of (Neo)adjuvant Chemotherapy423
     16.11Malignant Lymphoma424
     16.12Diffuse Large B-cell Lymphoma424
     16.13Burkitt's Lymphoma425
     16.14Extranodal Marginal-Zone B-cell Lymphoma of MALT Type425
     16.15Follicular Lymphoma425
    17Cytopathology of Benign and Malignant Lesions (Selected Topics)
     17.1Introduction440
     17.2Fibrocystic Change440
     17.3Proliferative Breast Diseases Without Atypia (Adenosis, Ductal Hyperplasia)440
     17.4Proliferative Breast Lesions with Atypia441
     17.5Lactating Adenoma and Lactating Changes441
     17.6Fibroadenoma441
     17.7Intraductal Papilloma441
     17.8Ductal Intraepithelial Neoplasia (Ductal Carcinoma In Situ)441
     17.9Lobular Intraepithelial Neoplasia442
     17.10Intraductal Papillary Carcinoma442
     17.11Infiltrating Ductal Carcinoma442
     17.12Infiltrating Lobular Carcinoma442
     17.13Tubular Carcinoma443
     17.14Mucinous Carcinoma443
     17.15Medullary Carcinoma443
     17.16Apocrine Carcinoma443
     17.17Adenoid Cystic Carcinoma443
     17.18Metaplastic (Sarcomatoid) Carcinoma444
     17.19Phylloides (Phyllodes) Tumor444
     17.20Further Reading444
    18Immunohistochemistry (Selected Topics)
     18.1Role of Immunohistochemistry in Diagnostic Breast Pathology472
     18.2Immunohistochemistry in the Differential Diagnosis of Epithelial Lesions: Myoepithelial Cells472
     18.3Carcinomas with Myoepithelial Differentiation Versus Primary Sarcoma473
     18.4Microinvasive Carcinoma473
     18.5Cell Population in Intraductal Proliferative Lesions: Homogeneous Versus Heterogeneous Cell Population (Neoplasia Versus Hyperplasia)473
     18.6Paget's Disease474
     18.7Distinction Between DIN (DCIS) and UN (LCIS)474
     18.8Systemic Metastasis of Breast Carcinoma474
     18.9Micrometastatic Disease in Axillary Lymph Nodes (Including Sentinel Nodes)474
     18.10Immunohistochemistry for Prognostic or Predictive Factors in Breast Carcinoma: Hormone Receptors475
     18.11HER2/neu Overexpression475
     18.12Further Reading475
    Subject Index493



    Vorwort

    Preface

    Several excellent and comprehensive textbooks have been written on breast pathology [1-5]. The magnificent book Problems in Breast Pathology [1] written by John G. Azzopardi, and two more recent great works by Fattaneh A. Tavassoli [4] and Paul P. Rosen [3] cover almost all aspects of classic and modern breast pathology. So why should one dare to write a new book on this subject?

    Over the past few years, the Department of Pathology, Medical University Graz has organized annual intensive 5-day courses on diagnostic breast pathology in order to share the experience in this field and demonstrate and discuss several common diagnostic problems, including tumor-like lesions, intraductal proliferative lesions, variants of ductal and lobular intraepithelial neoplasias, papillary neoplasms, and a variety of infiltrating breast carcinomas. During these courses, it has been my constant experience that most practicing pathologists and pathologists in training appreciate receiving a precise summary of the diagnostic criteria for each entity combined with a brief and accurate discussion of the main differential diagnoses. In dealing with a variety of breast lesions in daily practice, surgical pathologists want and need to know the essentials of diagnostic breast pathology.

    So, the idea to write this book gradually evolved from these diagnostic courses, with a main focus on the essentials. This book is therefore designed as a diagnostic aid for pathologists when they encounter common as well as unusual or even challenging and very difficult cases. In trying to achieve this goal, it was necessary to reduce the text but emphasize case presentations that deal with the described entities. Indeed, this book contains over 1,100 full-color illustrations demonstrating gross, histologic, cytologic, and immunohistochemical findings of common as well as challenging benign and malignant breast lesions.

    I am most grateful to Dr. Fattaneh A. Tavassoli for her constructive comments, suggestions, and encouragement throughout the preparation of this book. I am indebted to the staff pathologists at the Department of Pathology, Medical University Graz, who have supported me during the preparation of this book. I am thankful to Drs. Helmut Denk, Manfred Ratschek and Wolfgang Öhlinger for their kind support. I would like to acknowledge the excellent assistance and expertise of Mrs. Andrea Kaps in preparing the photomicrographs. I would like to thank the staff of the publisher, Springer, in particular Mrs. Gabriele M. Schröder and Mrs. Ellen Blasig for their professional and efficient cooperation and consideration in the production of this book.

    Once again, I would like to express my special thanks to my wife, Shokufeh Sodeifi-Moinfar, for her support and tolerance over the past three years.

    Graz, Austria
    November 2006

    Farid Moinfar

    References

    1. Azzopardi JG. Problems in breast pathology. WB Saunders, London, 1979.
    2. Page DL, Anderson TJ. Diagnostic histopathology of the breast. Churchill Livingstone, Edinburgh, 1987.
    3. Rosen PP. Rosen's breast pathology, 2nd edn. Lippincott Williams & Wilkins, Philadelphia, 2001.
    4. Tavassoli FA. Pathology of the breast, 2nd edn. Appleton & Lange, Stamford, CT, 1999.
    5. Tavassoli FA, Devilee P (eds). World Health Organization classification of tumours. Pathology and genetics. Tumours of the breast and female genital organs. IARC Press, Lyon, 2003

    Klappentext

    This abundantly illustrated reference work focuses on the essential information needed by pathologists in order to interpret breast lesions (tumors) appropriately. Particular attention is paid to the diagnostic criteria with systematic analysis of differential diagnoses. Value and limitations of immunohistochemistry as a diagnostic adjunct are demonstrated as well. Using a systematic approach, this book contains the fundamental information required to avoid misinterpreting breast lesions and thus the under or overtreatment of patients.

    Moinfar
    Essentials of Diagnostics
    Breast Pathology
    A Practical Approach

    ISBN 978-3-540-45117-4

    Reviews

    From the reviews: "The pathologist-in-training and general pathologist will benefit from the addition of Dr Farid Monifar's Essentials of Diagnostic Breast Pathology: A Practical Approach to their personal library. The goal of this 470-page combination text-atlas is to serve as an efficient reference to both educate and update the practicing diagnostician through guiding the processing, microscopic analysis, and clinico-pathologic correlation of a wide spectrum of common and uncommon breast lesions. Monifar uses focused and captioned text describing more than 1100 full-color illustrations to aid in this challenging task." (Giovanna Crisi, Journal of the American Medical Association, Vol. 298 (15), 2007) "This is a succinct and practical guide to diagnosis of breast disease with over 1,100 full-color illustrations demonstrating gross, histologic, cytologic, and immunohistochemical findings of common and challenging breast lesions. The text is short and precise and each disease entity is emphasized with case presentations. ... a nice addition to the existing breast pathology books as it stresses specifically the practical diagnostic essentials in breast pathology. ... written for practicing pathologists and pathologists in training who deal with breast pathology on a daily basis." (Fang Fan, Ph.D, MD, Doody's Review Service, March, 2008)