DeutschesFachbuch.de : Pediatric Oncology

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Contents
Foreword v
Eugenie S. Kleinerman
Preface vii
Contributors xiii
Chapter 1
Acute Leukemia 1
Michael E. Rytting, Mary S. Choroszy, Demetrios Petropoulos, and Ka Wah Chan
Chapter 2
Hodgkin Lymphoma and Non-Hodgkin Lymphoma 18
Ka Wah Chan, Demetrios Petropoulos, Eric L. Chang, and Michael E. Rytting
Chapter 3
Brain Tumors: Diagnosis, Surgery and Radiotherapy, and Supportive Care 30
Joann L. Ater, Jeffrey S. Weinberg, Moshe H. Maor, Bartlett D. Moore, III, and Donna ...
Chapter 4
Brain Tumors: Chemotherapy and Investigational Therapy 50
Joann L. Ater, Jeffrey S. Weinberg, Moshe H. Maor, and Demetrios Petropoulos
Chapter 5
Wilms' Tumor 70
Norman Jaffe and Margaret G. Pearson
Chapter 6
Neuroblastoma 82
Joann L. Ater and Laura L. Worth
Chapter 7
Soft-Tissue Tumors 96
R. Beverly Raney, Richard J. Andrassy, Martin Blakely, Tina V. Fanning, Moshe H. Maor...
Chapter 8
Osteosarcoma 110
Norman Jaffe and Margaret G. Pearson
Chapter 9
Ewing's Sarcoma 121
Cynthia E. Herzog, Anita Mahajan, and Valerae O. Lewis
Chapter 10
Retinoblastoma 142
Misha Taustina, Cynthia E. Herzog, and Dan S. Combos
Chapter 11
Differentiated Thyroid Cancer 155
Rena Vassilopoulou-Sellin
Chapter 12
Medullary Thyroid Carcinoma 167
Robert T Gagel
Chapter 13
Melanoma 180
Cynthia E. Herzog, Hafeez Diwan, Merrick I. Ross,and Victor G. Prieto
Chapter 14
Novel Therapeutic Approaches 194
Sima S. Jeha and Laura L. Worth
Chapter 15
Supportive Care: Myelosuppression 208
Nidra I. Rodriguez Cruz, Renee M. Madden, and Craig A. Mullen
Chapter 16
Supportive Care: Symptom Control 218
Renee M. Madden, Susannah E. Koontz-Webb, Donna S. Zhukovsky,and Craig A. Mullen
Chapter 17
Behavioral Medicine in Cancer Care 244
Donna R. Copeland and Martha A. Askins
Chapter 18
The Adolescent and Young Adult Program 256
Sima S. ]eha and Martha A. Askins
Index 268
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Index
AAbstinence syndrome, from opioids, 234
ABVD regimen, for Hodgkin lymphoma, 22
Academic interventions, 250-252
- community-school program, 252
- homebound education program, 263
- hospital-based schooling, 250-251
Acetaminophen, 233, 235
Actinomycin D for Ewing's sarcoma, 126-127
- for rhabdomyosarcoma, 104, 105
Acute lymphoblastic leukemia (ALL), 2-8
- brain metastases of, 64
- diagnosis of, 3-4
- epidemiology of, 2
- etiology and predisposing
- factors in, 2
- flow cytometric classification of, 4
hematopoietic stem cell transplantation for, 5-7
- in infants, 8
- improving treatment outcomes for, 258-259
- mature B-cell, 8-10
- molecular genetic abnormalities in, 2-3
- supportive care for, 7-8- treatment and prognosis with, 4-5
Acute myeloid leukemia (AML). See Myeloid leukemia
Acute promyelocytic leukemia (APL), 11-15
- diagnosis of, 10-11
- supportive care for, 11-12
- treatment of primary disease in, 13
- treatment of relapsed disease in, 13
Acyclovir, as prophylaxis, 213
Addiction, opioid, 234
Adjuvant analgesics, 231, 233, 235
Adolescent and young adult patients, 256-267
- epidemiology of cancer in, 257
- improving quality of life for, 260-265 (See also Quality of life)
- improving treatment outcomes for, 258-260
- multidisciplinary program
- design for, 258
- pediatric-versus-adult protocols for, 257
- promoting awareness of issues specific to, 266
- special program for, 257-258
Aggressive fibromatosis. See Fibromatosis, aggressive
All-trans retinoic acid (ATRA), for leukemia, 13
Allopurinol, for mature B-cell leukemia, 9
Aminoglycosides, for febrile neutropenia, 210
Amoxicillin, for febrile neutropenia, 211
Amphotericin, for febrile neutropenia, 210
Amsacrine, for myeloid leukemia, 12
Analgesic pharmacotherapy, 233-236. See also specific
agents administration principles in, 235
administration routes in, 235-236
- nonopioids and adjuvant analgesics in, 233
- opioids in, 233-234
Anaplastic astrocytoma, 58. See also Glioma, high-grade
Anaplastic large-cell lymphoma (ALCL), 24-28. See also Non-Hodgkin lymphoma
Anaplastic oligodendroglioma. See Glioma, high-grade
Anemia, 213-214
Anesthetics, local, for pain, 232-233
Anthracyclines. See also specific
agents adverse effects of, 118
Anti-CD 30 monoclonal antibody, for recurrent Hodgkin lymphoma, 23
Anti-GD 2 monoclonal antibodies, for neuroblastoma recurrence, 93
Antibacterial prophylaxis, 212
Anticonvulsants. See also specific
agents for pain, 233, 235
Antidepressants, tricyclic, for pain, 233, 235
Antimicrobial prophylaxis, 212-213
Antiprotozoal prophylaxis, 212
Antithrombin III, for hepatic veno-occlusive disease, 213
Antiviral prophylaxis, 213
Arsenic trioxide, relapsed for acute promyelocytic leukemia, 13
Aspirin, 233
Astrocytoma anaplastic, 58 (See also Glioma, high-grade)
- infantile desmoplastic, 51-53, 53 t
- low-grade, 51-53, 53 t
Atovaquone, as P. carinii prophylaxis, 212
ATRA syndrome, 13
Atypical nevus, 184-185, 185 f
Atypical teratoid/rhabdoid tumors.See Embryonal brain tumors
Azithromycin, for febrile neutropenia, 211
Azoles, for febrile neutropenia, 210
BB-cell leukemia Epstein-Barr virus in, 2
- mature, 8-10
- survival with, 5
- B-lymphoblastic lymphoma, precursor, 24
Bacterial infection, in cancer, 209-210, 210 f
BCNU, for Hodgkin lymphoma before HSCT, 23
BEAM for Hodgkin lymphoma recurrence, 23- for non-Hodgkin lymphoma recurrence, 28
Beckwith-Wiedemann syndrome, 71
Behavioral medicine, 244-255
- academic interventions in, 250-252
- neuropsychology in, 252-254
- psychologicand and emotional-support interventions in, 246-249
- psychosocial-support interventions in, 249-250
- supportive-care needs of patients and family members, 245-246
Benzodiazepines, for anticipatory vomiting, 223, 226
Bleomycin for Hodgkin lymphoma, 22
- for nongerminomatous germ-cell tumor, 63
Body image, in adolescent and young adult patients, 262-263
Bone marrow transplantation for neuroblastoma, 90-92
- psychosocial support for, 249
Brain tumors, 30-69. See also specific tumors
- astrocytomas, low-grade, 51-53, 53 t
- clinical presentation of, 31-33
- complications of, 67
- ependymoma, 61-62, 61 t
- epidemiology of, 31
- evaluation of, 33-34
- follow-up for, 43-47- follow-up for, audiologic and ophthalmologic, 47
- follow-up for, endocrine evaluation in, 46-47
- follow-up for, late neurologic effects in, 46
- follow-up for, neuropsychologic evaluation in, 44-46
- follow-up for, speech, occupation, and physical therapy in, 47
- germ-cell, 62-64
- glioma, high-grade, 57-61 (See also Glioma, high-grade)
- long-term care with, 67
- medulloblastoma and other embryonal tumors, 53-57
- metastatic, 64
- neurofibromatosis on diagnosis in, 34-35, 34 t
- neuropathology of, 35, 35 t recurrent, 64-66
- supportive care in, 44-47
- terminology for, 51
- treatment of, 35-43, 36 t
- treatment of, chemotherapy in, 43
- treatment of, high-dose chemotherapy and autologous stem cell rescue in, 66-67
- treatment of, neurosurgery in, 35-39 (See also-Neurosurgery, for brain tumors)- tre...
Brainstem glioma.See Glioma, high-grade
Burkitt-like lymphomas, 8, 24-28
Burkitt's lymphoma, 8, 24-28
- clinical presentation of, 24-25
- diagnosis and staging of, 25-26, 26 t
- epidemiology of, 24
- Epstein-Barr virus in, 2
- pathology and prognostic factors in, 25
- treatment of primary disease in, 27
- treatment of recurrent disease in, 27-28
Busulfan, for acute lymphoblastic leukemia before HSCT, 6
CCachexia, 223, 226
Calcitonin, in medullary thyroid carcinoma, 168, 168 f, 172
Calories, recommended daily allowances of, 226, 226 t, 228, 240-243
Cancer clinical trials, 195
Capsofungin, for febrile neutropenia, 210
Carbapenem, for febrile neutropenia, 209
Carboplatin adverse effects of, 149-150
- for astrocytomas, low-grade, 53, 53 t
- for germinomas, 63
- for neuroblastoma, 89
- for neuroblastoma recurrence, 92
- for retinoblastoma, 148-150
Carcinoembryonic antigen (CEA), in medullary thyroid carcinoma, 168
Carmustine, for Hodgkin lymphoma before HSCT, 23
CCNU for astrocytomas, low-grade, 53, 53 t- for ependymoma, 62
- for glioma, high-grade, 59, 60 t
- for medulloblastoma, 55-56
- for primitive neuroectodermal tumor, 56
Cefepime, for febrile neutropenia, 209, 210
Central nervous system tumors.See Brain tumors; specific tumors
Cephalosporin, fourth-generation, for febrile neutropenia, 209
Chemotherapy-induced nausea and vomiting, 219-223
Child-life specialists, 247
Chloromas, brain metastases of, 64
Chlorpromazine, 225 t
Chronic myeloid/myelogenous leukemia (CML).See Myeloid leukemia
Ciprofloxacin, for febrile neutropenia, 211
Cis-retinoic acid, for high-grade glioma, 59
Cisplatin adverse effects of, 118
- for astrocytomas, low-grade, 53, 53 t
- for ependymoma, 61-62
- for germinomas, 63
- for glioma, high-grade, 60 t
- for Hodgkin lymphoma before HSCT, 23- for Hodgkin lymphoma recurrence, 23
- for medulloblastoma, 55-56
- for melanoma, 190
- for neuroblastoma, 89- for neuroblastoma recurrence, 92- for nongerminomatous germ-...
- for primitive neuroectoderma tumor, 56
- for rhabdoid tumor of kidney, 77
Clark nevus, 184-185, 185 f
Clergy, 249
Clinical research, pediatric.See also Novel therapeutic approaches
Clinical research, pediatric (cont.) accrual in, 196-197
- biologic correlates in, 197
- enrollment criteria for, 205
- ethics of, 203-205
- regulatory requirements in, 196
- trials in, 195
Clinical target volume (CTV), 41, 135-137
Clofarabine
- for leukemia, 198 t, 199
- for relapsed acute myeloid leukemia, 13
Cognitive deficits, 44-46
Cognitive Remediation Program, 253-254
- with brain tumors, 44
Congenital mesoblastic nephroma, 78
Corticosteroids, for pain, 233
COX-2 inhibitors, for high-grade glioma, 59
Cranial nerve tumors, 32.See also Brain tumors
Cranial radiotherapy, side effects of, 252-253
Craniospinal radiotherapy (CSRT), 42-43
- for CNS germ-cell tumors, 63
- for medulloblastoma, 55
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