| VORWORT | öffnen |
|
PREFACE Molecular biologists' concept of cells is a "biological container" where important molecules float and interact with one another more or less randomly. However, a close view of this "bag" reveals an astonishing net of fibrous proteins crossing throughout the cytoplasm: the cytoskeleton. This structure is composed of three different elements: actin microfilaments, tubulin microtubules, and a third class denoted, due to their size, intermediate filaments (IF). This last network is built by...
[weiter lesen]
|
|
|
| KLAPPENTEXT | öffnen |
|
MOLECULAR BIOLOGY INTELLIGENCE UNIT Landes Bioscience, a bioscience publisher, is making a transition to the internet as Eurekah.com. INTELLIGENCE UNITS Biotechnology Intelligence UnitMedical Intelligence UnitMolecular Biology Intelligence UnitNeuroscience Intelligence Unit Tissue Engineering Intelligence Unit The chapters in this book, as well as the chapters of all of the five Intelligence Unit series, are available at our website. EUREKAH.COM ISBN 0-387-33780-6 [weiter lesen] |
|
|
| INHALTSVERZEICHNIS | öffnen |
CONTENTS
Prefaceix
1.Desmin and Other Intermediate Filaments in Normal and Diseased Muscle 1
Denise Paulin and Zhigang Xue
Desmin in Mature Skeletal and Heart Muscle Cells 1
Desmin and Other IF Proteins in Different Muscles 2
Functions of Desmin in Striated Muscles 4
Function of Desmin in Smooth Muscles 5
Gene Regulation 5
Desmin-Related Myopathies (DRM)6
2.Intermediate Filaments in Astrocytes in Health and Disease 10
Milos Pekny and Ulrika Wilhelmsson
IFs in Astroglial Cells during Development 10
GFAP and Its Regulation 11
Vimentin and Nestin and Their Regulation 13
Formation of IFs in Astroglial Cells 13
Astrocyte IFs, CNS Trauma and Regeneration 16
Astrocyte IFs and Resistance to Mechanical Stress 22
Astrocyte IFs, Osmotic Stress and Ischemia/Hypoxia 25
Astrocyte IFs, Cell Proliferation and Tumorigenesis 25
GFAP Mutations and Alexander Disease 26
3.Neuronal Intermediate Filaments and Neurodegenerative Diseases 35
Gee Y. Ching and Ronald K.H. Liem
Neuronal Intermediate Filament Proteins 36
Neuronal IFs in Neurodegenerative Diseases 38
4.Neurofilaments: Phosphorylation and Signal Transduction 52
Sashi Kesavapany, Richard H. Quarles and Harish C. Pant
Neurofilaments Are Members of the Intermediate Filament Family 53
Neurofilaments and Axonal Caliber 55
Phosphorylation of Neurofilaments 55
Neurofilaments and Their Associated Kinases 56
Neurofilament Tail Domain Phosphorylation 57
Axonal Transport of Neurofilaments 58
Phosphorylation of NFs and Disease 59
Neurofilaments and Signal Transduction Pathways 60
5.Keratin Intermediate Filaments and Diseases of the Skin 74
E.Birgitte Lane
Epidermal Blistering Caused by Keratin Mutations 74
Candidate Genes in Other Epithelia 75
From Candidate Genes to "Candidate Diseases"77
Supramolecular Stability versus Molecular Flux 77
Keratin Filaments as Tensile Structures 78
Significance of Keratin Role in Skin Fragility Disorders 79
6.The Keratin K 6 Minifamily of Genes 83
Manuel Navarro
Conservation of Sequence in the K 6 Polypeptides 84
Expression of the K 6 Genes 87
Expression and Partners 89
Functional Considerations 89
7.Transcriptional Regulation of Keratin Gene Expression 93
Miroslav Blumenberg
Transcriptional Regulation of Keratin K 5 Expression 93
Regulation of K 1495
Regulation of K 1596
Regulation of K 1 and K 1096
Regulation of K 4 and K 1397
Regulation of K 3 and K 1298
Regulation of Hair Keratins 99
Regulation of Keratin Gene Expression by Hormones and Vitamins 99
Regulation of Keratin Gene Expression by Growth Factors and Cytokines 101
Regulation of Small Keratins, K 7, K 8, K 18 and K 19101
Specific Transcription Factors Implicated in Regulation of Transcription of ...
Conclusions and Future Directions 105
8.Simple Epithelial Keratins: Expression, Function and Disease 110
M. Lianos Casanova, Ana Bravo and Jose L. Jorcano
Suggested Functions of Simple Epithelial Keratins 111
Simple Epithelial Keratin Proteins and Disease 114
[weiter lesen] |
|
|
|
|
| REGISTER | öffnen |
Index
Symbols 14-3-3 41, 113, 126, 141
A α-internexin 35-37, 39, 42, 44, 54
αB-crystallin 125
Actin 1, 41, 43, 53, 66, 77-79, 111, 132, 133
Aggregation 6, 7, 26, 40, 44, 45, 56, 59, 60, 75, 77, 78, 111, 120, 121, 123, 124, 13...
Akt 136-141
Alcoholic steatohepatitis (ASH) 120, 121, 123-126
Alexander disease 26, 27, 79
Amyotrophic lateral sclerosis (ALS) 35, 38-41, 43-45, 51, 52, 59, 60, 79
API 12, 13, 88, 89, 93-96, 98, 100-104
AP 2 88, 89, 93-99, 101, 103, 104
Apoptosis 114, 115, 125-127, 142
Astrocyte 3, 10-27
Axon 17, 20, 23, 35, 37-39, 41-45, 52-56, 58-61, 63, 64, 67, 69
Axonal transport 35, 39, 41-45, 52, 55, 58, 59
BBasal layer 74, 75, 83, 90, 94-97, 132, 134, 138, 141, 142
Blistering 74, 76, 77, 89, 114
CC/EBP 88, 89, 96, 98, 104
Calmodulin-dependent protein kinase (CAMK) 42, 52, 57
Cancer 97, 103, 110, 115, 116, 121, 122, 132
Casein kinase I/II (CKI/II) 42, 52, 57
Caspase 114, 120, 127
CBP/p 300 95, 102, 104
Cdk 4 45
Cdk 5 42, 43, 45, 52, 57-60, 62-65, 67-69
Charcot-Marie-Tooth disease 35, 39
Cholestasis 120, 121, 123
Cirrhosis 77, 120, 121, 127
Copper storage 121
Cyclin 42, 57, 97, 134, 138, 141
Cytoskeleton 1, 4-6, 25, 35, 36, 41, 44, 52-54, 56, 58, 64, 67, 74, 77-80, 83, 90, 11...
DDelta 99
Desmin 1-7, 56, 79
Desmin-related myopathies (DRM) 1, 5-7
Desmosomes 78, 79, 113, 124, 139, 140
- 3, 5-diethoxycarbonyl-1, 4-dihydrocollidine (DDC) 122-126
Differentiation 4, 6, 12, 20, 22, 41, 53-55, 65, 75, 76, 78, 83, 95-100, 105, 110, 12...
Disease 1, 6, 10, 16, 26, 27, 35, 38-41, 43-45, 52, 59, 60, 69, 74, 75, 77, 79, 80, 8...
Dorsal root ganglia neuron (DRG) 54, 55, 64-66, 69
Dynein 44, 45, 58, 59
EEnhanced green fluorescent (EGF) 22, 23, 40, 61, 88, 89, 100, 101
Enhancer 5, 6, 13, 88, 94, 99, 102, 103
Epidermis 22, 75, 76, 83, 90, 94-97, 99-101, 103, 111, 114, 115, 121, 131, 132, 134, ...
Epidermolysis bullosa simplex (EBS) 74-78
Epithelia 74, 75, 76, 77, 78, 79, 80, 83, 94, 95, 96, 97, 101, 102, 103, 105, 110, 11...
Epithelial 74, 75, 76, 77, 78, 79, 83, 93, 94, 95, 96, 97, 98, 99, 102, 105, 110, 111...
ERK 42, 52, 57, 58, 60, 61, 64-69, 126, 141
Ets 95, 97, 102, 104
FFas 113, 114, 126
GGene expression 11, 35, 40, 45, 93-103, 121, 131
Glia 10, 12, 16, 23, 63, 69
Glial fibrillary acidic protein (GFAP) 3, 10-27, 56, 79
Glucocorticoid receptor (GR) 96, 100, 104
Glycogen synthase kinase-3 (GSK 3) 42, 52, 57
Griseofulvin (GF) 122, 123, 126
HHepatocyte 77, 111-114, 120-125
HOX 99, 104
IIchthyosis bullosa of Siemens 76
Inducible expression 87, 88
Inflammatory bowel disease 77, 115
Integrin 52, 62, 64, 132, 141
Intermediate filament (IF) 1-7, 10, 13-20, 22, 23, 25, 28, 35-45, 52-56, 74, 75, 77-8...
JJun NH 2 -terminal kinase (JNK) 113, 114, 126
KKeratin (K) 1, 3, 22, 35, 74-80, 83-90, 93-105, 110-116, 120-127, 131-142
Keratinocyte 74, 75, 78, 79, 83, 84, 89, 94-101, 103, 115, 121, 131, 132, 134, 136-13...
Kinase 4, 13, 17, 35, 41-43, 45, 52, 56-65, 67-69, 86, 113, 114, 122, 125, 126, 134, ...
Kinesin 4, 44, 58, 59
Knock-out mice 4, 6, 60, 77, 89, 95, 111, 120-122, 125, 141
Krox 5, 6
Kruppel-like transcription factor (KLF) 97, 98, 103, 104
KSP 36, 37, 39, 40, 42, 43, 52-55, 57-59, 61, 62, 64, 67
LLewy body 38, 52, 59
Liver 77, 111-115, 120-124, 126, 127
Locus controlling region (LCR) 102, 103
Lymphoid enhancer factor 1 (LEF-1) 99
Lysine-serine-proline 37, 53, 54,
see also KSP
MMallorybody 77, 111, 120-126
Meesman corneal dystrophy (MCD) 76
Mitochondria 1, 4, 41, 42, 43, 44, 59, 121, 139, 140
Mitogen-activated protein kinase (MAP kinase) 43, 52, 57, 59-61, 63, 64
Monilethrix 76
Motif 54, 55, 58, 75-77, 96-99, 105
Muscle 1-7, 38, 39, 60, 79, 80
Myelin associated glycoprotein (MAG) 52, 63-67, 69
MyoD 5, 6
Myopathy 1, 5-7, 79
NNestin 1, 3, 4, 10, 13-16, 36, 37, 53, 54
Neurodegenerative disease 16, 27, 35, 38-41, 43, 45, 52, 59, 69
Neurofilament (NF) 13, 35-45, 52-69, 79, 95, 96
Neurons 10-12, 17, 22, 23, 26, 35-45, 52-56, 58-61, 63-67, 69, 112 NFKB 13, 95, 96,...
Nonalcoholic steatohepatitis (NASH)120-122, 124, 126, 127
Notch 99, 142
OOMIM 75-77, 79, 89, 138
Pp 62 121-125
Pachyonychia congenita (PC) 76, 86, 89, 90
Pancreas 103, 110-115, 138
Paranemin 1, 6
Parkinsons disease 38, 39, 52, 59
PAX 98, 104
Peripherin 35-42, 45, 53, 54, 60
Phosphorylation 13, 15, 35, 37, 39, 41-45, 52-69, 77, 78, 101, 113, 114, 122, 125-127...
Placenta 111
Plectin 6
Polarity 77, 112, 113
POU 95
Proliferation 10, 25, 26, 54, 76, 83, 87, 95, 97, 101, 110, 116, 120, 121, 126, 132, ...
Promoter 6, 11-13, 39, 87, 88, 93-99, 101-103, 114-116, 138, 139
Protein kinase A (PKA) 13, 42, 52, 56, 57
Protein kinase C (PKC) 13, 42, 56, 57, 113
Protein misfolding 120, 124, 125
Purkinje 2, 35, 39, 42
RRARE 88, 89
Retinoblastoma (Rb) 45, 99, 134, 136, 138, 139, 141, 142
Retinoic acid 62, 83, 93, 94, 96, 97, 99, 100, 102, 103
Rod domain 36, 41, 53, 54, 56, 76, 86, 111
SSignal transduction 52, 60, 62, 67-69, 80, 113, 116, 138, 139
Skin 74-77, 79, 80, 83, 89, 100, 101, 103, 111, 115, 116, 131, 136, 138, 139, 141
Skn-1 95, 104
Smooth muscle 1-3, 5
Spl 5, 6, 13, 93, 94, 97-99, 101-104
STAT 13
Steatocystoma multiplex 76, 89
Steatohepatitis 120-123
Superoxide dismutase (SOD) 35, 39, 43-45, 60
Syncoilin 3, 4, 6
Synemin 1, 3-6, 10, 15, 16
TT 3 R 99, 100, 104
TATA box 88, 97, 99, 102, 103
tau 43, 53, 59, 64, 66, 67, 68
Thymus 142
Thyroid hormone 93, 94, 96, 99, 100
Transcription factor 12, 88, 93-98, 100-105, 115
Transfection 26, 44, 56, 58, 61, 94-98, 100, 115, 122, 132, 134, 136
Transforming growth factor (TGF) 100, 101, 113
Transgenic mice 13, 26, 35, 37-40, 42-45, 55, 56, 60, 87, 94, 95, 99, 100, 102, 103, ...
Transitional cell carcinoma (TCC) 98, 115
Transport 13, 25, 35, 37, 39, 41-45, 52, 55, 56, 58-60, 113
Tubulin 43, 57, 60, 66, 77, 79, 132, 133
Tumor 25-27, 97, 101, 110, 114-116, 121, 126, 138-141
Tumor necrosis factor (TNF) 101, 111, 114, 115, 121, 126, 141
UUbiquitin 40, 121, 122, 124, 125
VVimentin 1-6, 10, 13-17, 23, 26, 36, 37, 53, 54, 56, 77, 115, 132, 133
Vitamin D 3 99
WWhite sponge naevus (WSN) 76
Whn 97, 104
Wound healing 18, 83, 86, 89, 90, 96, 121, 132
[weiter lesen] |
|
|
|
|