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Marc Thiriet
Biology and Mechanics of Blood Flows 1
Part I: Biology
erschienen Januar 2008
657 Seiten, 60 schw.-w. Abb., 60 schw.-w. Fotos, Gebunden
Springer-Verlag GmbH | ISBN: 0387748466
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Series Preface The Centre de recherches mathématiques (CRM) was created in 1968 by the Université de Montréal to promote research in the mathematical sciences. It is now a national institute that hosts several groups and holds special theme years, summer schools, workshops, and a postdoctoral program. The focus of its scientific activities ranges from pure to applied mathematics and includes statistics, theoretical computer science, mathematical methods in biology and life science...
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CRM Series in Mathematical Physics Marc Thiriet Biology and Mechanics of Blood Flows Part I: Biology Biology and Mechanics of Blood Flows presents the basic knowledge and state-of-the-art. techniques necessary to carry out investigations of the cardiovascular system using modeling and simulation. Part I of this two-volume sequence, Biology, addresses the nanoscopic and microscopic scales. The nanoscale corresponds to the scale of biochemical reaction cascades involved in cell adap... [weiter lesen] |
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Contents
Series PrefaceV
Introduction 1
1 The Cell 7
1.1 Cell Components 9
1.1.1 Cellular Membranes 9
1.1.2 Cell Nucleus 11
1.1.3 Endoplasmic Reticulum 14
1.1.4 Golgi Apparatus 15
1.1.5 Mitochondria 16
1.1.6 Cytoskeleton 17
1.1.7 Vesicles 17
1.1.8 Ribosomes 18
1.2 Cell Fate 18
1.2.1 Sirtuins 21
1.2.2 Cell Growth 22
1.2.3 Protein Synthesis 23
1.2.4 Circadian Clock 28
1.2.5 Cell Division 29
1.2.6 Cell Decision between Survival or Death 32
1.2.7 Caspases 32
1.2.8 Cell Autophagy 35
1.2.9 Cell Senescence 36
1.2.10 Cell Apoptosis 37
1.2.11 Cell Necrosis 38
1.3 Cellular Membranes 38
1.4 Mitochondrion 41
1.5 Cell Cytoskeleton 47
1.5.1 Microfilaments 48
1.5.2 Microtubules 50
1.5.3 Intermediate Filaments 52
1.5.4 Modeling of the Cytoskeleton Mechanics 54
2 Plasma Membrane and Cell Environment 57
2.1 Plasmalemma 57
2.1.1 Glycerophospholipids 60
2.1.2 Phosphoinositides 61
2.1.3 Cholesterol 64
2.1.4 Membrane Rafts 67
2.1.5 Proteins 67
2.1.6 Glucids 68
2.2 Adhesion Molecules 69
2.2.1 Cadherins 69
2.2.2 Selectins 70
2.2.3 Integrins 71
2.2.4 Immunoglobulin-Like Cell Adhesion Molecules 74
2.2.5 Focal Adhesions 75
2.3 Cellular Junctions 76
2.3.1 Desmosomes 76
2.3.2 Zonula Adherens 77
2.3.3 Tight Junctions 79
2.3.4 Gap Junctions 80
2.3.5 Mechanical Effects 81
2.4 Extracellular Matrix 81
2.4.1 Structural Proteins 82
2.4.2 Matrix Metalloproteinases 83
2.4.3 Basement Membrane 86
2.4.4 Interstitial Matrix 88
3 Ion Carriers and Receptors 93
3.1 Membrane Carriers 93
3.1.1 Ion Carriers 95
3.1.2 Molecule Carriers 112
3.2 Plasmalemmal Receptors 113
3.2.1 G-Protein-coupled Receptors 115
3.2.2 Receptor Tyrosine Kinases 135
3.2.3 Receptor Serine/Threonine Kinases 142
3.2.4 Receptor Tyrosine Phosphatases 142
3.2.5 Semaphorins and Plexins 143
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Index
A α-actinin 49, 316
α-adrenergic receptor 121, 123, 186, 429
A-kinase anchoring protein 198, 209, 210, 213, 215, 324, 351, 352
Aaa protein 51
ABC carrier 65, 113
acetyl-CoA synthetase 45
acetylcholine 95, 119, 198, 307, 372, 373, 381, 389, 397, 420, 428
Ack kinase 74
actin 13, 18, 48, 49, 55, 64, 69-71, 74-76, 78, 82, 83, 170, 171, 189, 194, 238, 240,...
actin-binding protein 48
actin-severing protein 48
actinin 49, 53, 316
action potential 107, 308, 342, 344
activin 142
acyl CoA-cholesterol acyltransferase 64
adaptin 252
adaptor 18, 237, 240, 244, 246, 249, 251, 252
adenosine 120
adenosine diphosphate 120, 284, 389, 429
adenosine triphosphate 16, 20, 57, 120, 219, 220, 307, 313, 373, 389, 390, 428
adenylyl cyclase 187, 188, 220, 331, 352, 375, 444, 502, 503
adenylyl cyclase-activating polypeptide 499
adhesion molecule 69, 432, 433, 476
adipokine 301, 508
adiponectin 173, 301, 508, 509
adrenaline 95, 351, 503
adrenal cortex 504
adrenal medulla 503
adrenocorticotropic hormone 498, 505
adrenomedullin 388, 398, 469, 504
adventitia 360
aggresome 25, 27
aging 36, 207, 328
agmatine 427
albumin 269
aldosterone 301, 504
AMP-activated protein kinase 35, 45, 173, 174, 208, 302, 511
amphiphysin 250, 251
amylin 503
androgen 505
aneurism 85
anginex 474
angiogenesis 13, 146, 245, 388, 453, 456
angioinhibin 473
angiopoietin 142, 286, 457, 463, 470, 474, 478
angiostatin 473
angiotensin 123, 124, 134, 139, 140, 200, 231, 301, 322, 397, 483, 505
ankyrin 74, 100, 319, 321
annexin 212, 240
antiporter 94
aortic valve 302
apolipoprotein 270, 274, 433
apoptosis 16, 19, 35, 37, 198
apoptosis signal-regulating kinase 176, 204, 206
apoptosome 33
aquaporin 112
Arf protein 194, 243
arginine 427
argonaute 27
arrestin 134, 137, 144, 179, 215, 467
artemin 373
arterial pressure 499
arteriogenesis 453, 475
atherosclerosis 85, 196
atrioventricular node 306
atrium 321
autophagy 19, 35
avascularity 471
B ß-adrenergic receptor 121, 124, 134, 213, 351, 352, 390
Bachman bundle 306
backward difference 548
basement membrane 86, 364, 371, 380, 396, 398, 405, 406, 408
basophil 280
BCL 2 protein 38, 424, 483
bile acid 274
bioreactor 450
Biot number 412
bitesize 77
Blasius formula 536
blood-brain barrier 365
bone morphogenetic protein 142, 321
bradykinin 124, 231, 390, 428, 429, 480
Cc-Jun N-terminal kinase 179
C-reactive protein 477
Cadherin 69, 70, 76, 77, 79, 82, 171, 217, 424, 443, 473
calcineurin 183, 320, 322, 327, 483
calcitonin 502
calcitonin gene-related peptide 502, 504
calcium 16, 54, 219, 310, 319, 321, 341, 347, 348, 350, 351, 374, 377, 401, 420, 429,...
calcium-sensing receptor 124
calcium oscillation 225
calcium sensitization 180
calcium spark 311
calcium transient 198, 225
caldesmon 375
calmodulin 63, 122, 169, 171, 176, 183, 188, 189, 214, 219, 220, 223, 349, 374, 375, ...
calpain 321
calponin 377
calsarcin 320, 483
calsequestrin 349
cAMP response element 395
capillary 364, 365, 367, 403
cardiolipin 44
cardiomyocyte 44, 103, 137, 143, 145, 152, 188, 197, 229, 231, 253, 302, 307, 341, 48...
cardiomyopathy 83, 327, 350
cardiotrophin 325
caspase 32, 37, 263
catecholamine 301, 322, 345
catenin 69, 70, 78, 82, 147, 149, 424, 443
caveola 59, 214, 237, 244, 253, 351
caveolin 59, 212, 240, 245, 253, 256, 351, 405, 423
CaV channel 102, 181, 198, 329, 391
Cdc 42 protein 74, 191, 192, 218, 248, 256, 259, 260, 431, 444
cell membrane 19, 57, 93, 161, 164, 177
cell nucleus 8, 9, 11, 14, 94, 152, 185
central difference 548
centriole 52
centrosome 52
cerebrospinal fluid 368
chemokine 257, 277, 281, 407, 477, 479
chemokine receptor 277, 478
Chemotaxis 259, 263, 444, 445, 453, 487
cholesterol 58, 59, 64, 67, 271
chondromodulin 298, 472
choroid plexus 368
chromatin 12, 27
chromosome 12
chronophin 48
chronotropy 351
chylomicron 269, 372
cingulin 79
circadian rhythm 29
Clairaut number 329
clathrin 67, 240, 249, 252, 405
clathrin-coated pit 134, 240, 246, 249, 251
claudin 79, 369
Cloned-out of library 191
clotting 283, 411
coagulation factor 83, 412
coat protein 240, 243
cofilin 48, 180, 263, 443
collagen 55, 68, 77, 85, 87-89, 218, 301, 303, 308, 359, 392, 397, 414, 452, 458, 485...
colony stimulating factor 289, 483
complement 115, 280, 477, 480, 481
connexon 80
cortactin 48
corticotropin-releasing hormone 498
Cortisol 504
costamere 315, 316, 321
CRAC channel 101
creatine 45
creatine kinase 45, 221
cross-talk 164, 322
cyclic adenosine monophosphate 68, 121, 169, 198, 211, 213, 220, 243, 401
cyclic guanosine monophosphate 68, 169, 198, 215, 389, 401, 405
cyclin 14, 31, 178, 458
cyclin-dependent kinase 31, 322
cyclooxygenase 85, 128, 149, 153, 180, 302, 369, 433, 471
cytochrome C 35, 37, 40, 41, 44, 45
cytokine 276, 288, 289, 384, 428, 436, 477, 481
cytokine receptor 115, 170, 276
cytoplasma 9
cytoskeleton 47, 59, 69, 70, 238, 254, 405, 418, 424, 458
cytosol 9
DDamköhler number 412
Darcy-Weisbach formula 536
Darcy law 533
dendritic cell 282
desmin 315, 321
desmocollin 76
desmoglein 76
desmosine 88
desmosome 76, 308
diacylglycerol 64, 99, 167, 169, 222, 323, 382
diacylglycerol receptor 173
diastole 308, 310, 349
diffusion 487
digestive tract 506
Disheveled 83, 134, 147, 149
Dispatched 146, 149
dispersion 533
DNA 12, 17, 23
dopamine 498
dynamin 245, 248
dynein 51, 238
dyslipidemia 274
dystroglycan 87, 316
Eectoenzyme 409
EF-hand effector 223
eicosanoid 383-386, 477
elastic artery 360
elastic lamina 360
elastic modulus 89, 90, 362
elastin 82, 85, 88, 359, 392
elastin-laminin receptor 421
elastonectine 88
electrochemical delay 353
electrolyte 266, 267
electrotaxis 453
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