DeutschesFachbuch.de : Electrical Diseases of the Heart Genetics, Mechanisms, Treatment, Prevention

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Contents
Foreword by Douglas P. Zipesvii
Contributorsxv
Part I Basic Foundations of Normal and Abnormal Cardiac Electrical Activity
Edited by Charles Antzelevitch and Arthur A.M.Wilde
The Past and Promise of Basic Cardiac Electrophysiology 3
Harry A. Fozzard
1 Basic Physiology of Ion Channel Function 11
Isabelle Baró and Denis Escande
2 Developmental Aspects of the Electrophysiology of the Heart: Function Foll...
Alex V. Postma, Vincent M. Christoffels, and Antoon F.M. Moorman
3 Anatomic and Histopathological Characteristics of the Conductive Tissues of...
Cristina Basso, Siew Yen Ho, and Gaetano Thiene
4 Neural Regulation of the Heart in Health and Disease 52
Richard L. Verrier
5 Mechanisms of Cardiac Arrhythmia 65
Charles Antzelevitch, Alexander Burashnikov, and José M. Di Diego
6 Mechanisms of Action of Antiarrhythmic Drugs 133
Shingo Murakami and Yoshihisa Kurachi
7 Mechanoelectrical Interactions and Their Role in Electrical Function of th...
John Jeremy Rice and Peter Kohl
8 The Role of Cellular Sodium and Calcium Loading in Cardiac Energetics an...
John C. Shryock, Luiz Belardinelli, and Sridharan Rajamani
9 Sodium Ion Channelopathies 170
Simona Casini, Arthur A.M. Wilde, and Hanno L. Tan
10 L-Type Calcium Channel Disease 187
Yanfei Ruan, Raffaella Bloise, Carlo Napolitano, and Silvia G. Priori
11 K+Channelopathies (JKsand 7 Kr)194
Nicolas Lindegger and Robert S. Kass
12 Channelopathies of Cardiac Inwardly Rectifying Potassium Channels 207
Andre Terzic, Michel Vivaudou, Christophe Moreau, Timothy M. Olson, Arshad ...
13 Calcium Release Channels (Ryanodine Receptors) and Arrhythmogenesis 218
Subeena Sood and Xander H.T. Wehrens
14 Caveolae and Arrhythmogenesis 232
Matteo Vatta
15 Senescence and Arrhythmogenesis 247
Arshad Jahangir, Srinivasan Sattiraju, and Win-Kuang Shen
16 Comparisons of Substrates Responsible for Atrial Versus Ventricular Fibril...
Brett Burstein, Philippe Comtois, and Stanley Nattel
17 Single Nucleotide Polymorphisms in Health and Cardiac Disease 281
Eric Schulze-Bahr
18 Electrophysiological Remodeling in Dilated Cardiomyopathy and Heart Failure...
Fadi G. Akar and Gordon F. Tomaselli
19 Ventricular Electrical Remodeling in Compensated Cardiac Hypertrophy 305
Stephan K.G. Winckels and Marc A. Vos
20 Physiological and Other Biological Pacemakers 316
Michael R. Rosen, Peter R. Brink, Ira S. Cohen, and Richard B. Robinson
Part II Clinical Rhythmology: Diagnostic Methods and Tools
Edited by Win-Kuang Shen, Michael J. Ackerman, Paul A. Friedman, Arthur A....
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Index
AA. See Adenine
AADs. See Antiarrhythmic drugs
AAI. See Atrial-based pacing Abandoned leads, 791
ABCD. See Alternans before
- Cardioverter-Defibrillator trial Ablation, 7. See also Radiofrequency
ablation alcohol septal, 44
- with ARVC, 650, 834-836
- of atrioventricular node, 844
- with ATS, 832
- with BS, 830-831
- Holter monitoring after, 828-830
- with LQTS, 831-832
- septal, 620
- with VF, 826-836
- with VT, 826-836 for WPW, 665-666
- Absorption, 694
AC. See Adenyl cyclase
ACC/AHA/NASPE. See American College of Cardiology/ American Heart Association/North A...
ACE. See Angiotensin-converting enzyme ACEI. See Angiotensin-converting
- enzyme inhibitors Acetylcholine, 140
APD and, 507-508
- binding of, 53
- hyperpolarization by, 67
- repolarization and, 109
- in SAN, 318
- for SQTS, 557
Acetylcholine receptors, 6
- cloning of, 194
Acidosis
- EADs and, 72
- SQTS and, 557
Acquired Brugada syndrome
AADs and, 721-723
ajmaline and, 722
amitriptyline and, 723
- diltiazem and, 723
- disopyramide and, 722
- electrolytes and, 179, 725
- flecainide and, 721
- hyperthermia and, 179, 724-725
- hypothermia and, 179, 724-725
- insulin and, 179, 725
- lidocaine and, 722
- mexiletine and, 722
- nicorandil and, 723
- pilsicainide and, 721
- procainamide and, 722
- ST segment and, 179
- verapamil and, 722
Acquired cardiac arrhythmias, 179
Acquired drug-induced long QT syndrome (ADILQTS), 99-100, 179-180, 678, 705-716
- diagnosis of, 713-715
- risk factors for, 707, 713-715
a-actinin-2, 239
Action potential (AP), 4, 14-15
- with abnormal automaticity, 68
- in cardiomyocytes, 32
- with EADs, 261
- with ECC, 146
- ion currents and, 32
- in LQTS, 17
- in regions of heart, 16
- upstroke of, 18
Action potential duration (APD), 73, 86, 305, 309, 395
AADs and, 134
acetylcholine and, 507-508
ATR and, 272
- with CHF, 267-268
- EADs and, 73, 693
- electrolytes and, 694
- fibrillation and, 264
- HF and, 291-292
- hypokalemia and, 694
- INa and, 165, 180
- J-wave and, 507
- K+ channel and, 693
- monophasic, 308-309, 512
- repolarization and, 307
- sodium current and, 294
Activation, 13-14
Activation recovery intervals (ARIs), 512
Acute aortic dissection, 491
Acute Infarction Ramipril Efficacy Study (AIRE), 763
Acute mechanical stimulation, 155
Acute myocardial ischemia, 44
Acute pulmonary embolism, 491
Acute rejection, 45
Acute rheumatic carditis, 45
Acute ventricular dilation, 877-888
Adams-Stokes seizures, 316
Adenine (A), 445
Adenosine, 143-144, 425
- ventricular tachyarrhythmias and, 144
Adenosine triphosphate (ATP), 150, 199, 211, 318
- INa and, 163
Adenyl cyclase (AC), 53, 199
ADP, 211
- oc-adrenergic receptors, 55-56
- ß-adrenergic receptors, 53, 67
AADs and, 134, 140
activation of, 54-55
- epinephrine and, 199
- RyRs and, 221
- senescence and, 248
- stress and, 59
Advanced Technologies
- Biomagnetics, 382
AEDs. See Automated external
- defibrillators Aerobic training, 369
AF. See Atrial fibrillation Afterdepolarizations. See also Delayed afterdepolarizatio...
Aging. See Senescence AHI. See Apnea-hypopneaindex AIRE. See Acute Infarction
- Ramipril Efficacy Study Ajmaline, 429, 699
acquired BS and, 722 for BS, 92, 98, 489
Albuminuria, 939
Albuterol, 477
Alcoholism, 394
Alcohol septal ablation, 44
Aldactone, 764
Aldosterone receptor antagonists, 765
Algorithms
- Biotronik SMART, 790
- ELA Parad+, 790
- Guidant, 790, 793- for ICDs, 786-791
- Medtronic, 790
- morphology, 787- onset, 787- stability, 787
- St. Jude Morphology
- Discrimination, 787, 790, 793
Allelic drop-out, 452
Allograft vasculopathy, 43
Alternans Before Cardioverter-Defibrillator trial (ABCD), 399
Ambulatory monitoring, 344-351
American College of Cardiology/ American Heart Association/North American Society for...
American Health Insurance Portability and Accountability Act (HIPAA), 823
Aminophylline, 143
Amiodarone, 140, 251, 285, 413, 784
ADILQTS and, 179- for ARVC, 650
- for BS, 521- digitalis and, 700- for HCM, 619- with ICDs, 747
- INa and, 165
- for ischemic heart disease, 742-743- for LQTS, 102 studies of, 737-738
- tachyarrhythmias from, 706
- TWA and, 404 for WPW, 664, 665
Amiodarone Versus Implantable Cardioverter-Defibrillator Trial (AMIOVERT), 740, 742
AMIOVERT. See Amiodarone Versus Implantable Cardioverter-Defibrillator Trial Amitript...
acquired BS and, 723
Amlodipine, 142
AMP-activated protein kinase (AMPK), 660
Amphotericin B, 708
AMPK. See AMP-activated protein
- kinase Andersen cardiodysrhythmic periodic paralysis syndrome. See Andersen-Tawil s...
Andersen syndrome. See Andersen-Tawil syndrome Andersen-Tawil syndrome (ATS), 69, 203...
ablation with, 832
- cellular basis of, 547-548
- genetics and, 444
- genetic testing for, 455-456
- PVC with, 546
- SCD and, 894
Anger, 59
Angina pectoris, 386-387
Angiotensin-Converting enzyme (ACE), 7, 297, 312
- SCD and, 760
Angiotensin-Converting enzyme inhibitors (ACEI), 251, 730
- for HCM, 619
- remote management of, 811
- SCD and, 880
Angiotensin II receptor blockers (ARBs), 880
Angiotensin receptor antagonists, 251
Angitides, 45
Anions, 11-12
Anisotropy, 248
Annulus, 39
ANS. See Autonomic nervous
- system Anthracycline, 76
Antianginal drugs, 723
Antiarrhythmic drugs (AADs), 133-144, 250-251, 411, 784-785
acquired BS and, 721-723
APD and, 134
automaticity and, 135-136
- for BS, 521
- for CHF, 741-742
- classes of, 134
- DADs and, 135-136
- EADs and, 135-136
- ICDs and, 745-749
- ion channels and, 133
- reentry and, 135-136
- SCD and, 733-751, 881
- for VT, 412-413, 733
- for WPW, 664
Antiarrhythmics versus Implantable Defibrillators (AVID), 519, 738, 739, 774, 781, 88...
Antidepressants, 723
Anti-La antibodies, 45
Anti-Ro antibodies, 45
Antitachycardia pacing (ATP), 776, 782-784
- quality of life and, 776
AP. See Action potential
APD. See Action potential duration
ApEn. See Approximate entropy Apnea, 60, 892, 893. See also
- Obstructive sleep apnea SIDS and, 924
Apnea-hypopnea index (AHI), 900
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